Mechanisms Associated with Human Alveolar Macrophage Stimulation by Particulates
نویسندگان
چکیده
منابع مشابه
Mechanisms associated with human alveolar macrophage stimulation by particulates.
Asbestos and silica are well-known fibrogenic dusts. However, there is no comprehensive understanding of the molecular and cellular events that lead to fibrosis as a consequence of asbestos or silica inhalation. Previous studies have shown that asbestos stimulates superoxide anion production in alveolar macrophages through the phospholipase C/protein kinase C pathway. In contrast, silica does n...
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We applied flow cytometric analysis to characterize the in vitro response of alveolar macrophages (AM) to air pollution particulates. Normal hamster AM were incubated with varying concentrations of residual oil fly ash (ROFA) or concentrated ambient air particulates (CAP). We found a dose-dependent increase in AM-associated right angle light scatter (RAS) after uptake of ROFA (e.g., mean channe...
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The occurrence of emphysema in people deficient in alphai-antltrypsin and the production of emphysema in experimental animals with elastolytic enzymes suggest proteolysis as a mechanism for the development of emphysema. To investigate the possible role of pulmonary alveolar macrophages in the pathogenesis of emphysema, we measured elastase, acid protease, and elastaselike esterase activities in...
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Pulmonary diseases associated with inhalation of environmental or occupational particulates can be endpoints of a chronic inflammatory process in which alveolar macrophages (AM) play a pivotal role [1]. Figure 1 shows a ‘smiling’ human AM found in a bronchoalveolar lavage specimen [2]. AM are located in the alveolus, persistently exposed to pollute air, and serve as a first line of defense agai...
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Previous studies have shown that electrical stimulation (ES) increases blood flow, but the exact mechanisms are not clear. The present study was designed to clarify some of the underlying mechanisms involved in this phenomenon. White adult rabbits Lt.-6 months old were used. Animals were anesthetized by sodium pentobarbital (40 mg/kg, IV) and skin blood flow in the thoracic back was recorde...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1994
ISSN: 0091-6765
DOI: 10.2307/3432218